Final shuttle-derived atmospheric database: Development and results from thirty-two flights

The final Shuttle-derived atmospheric data base is presented. The relational data base is comprised of data from 32 Space Transportation System (STS) descent flights, to include available meteorology data taken in support of each flight. For the most part, the available data are restricted to the middle atmosphere. In situ accelerations, sensed by the tri-redundant Inertial Measurement Unit (IMU) to an accuracy better than 1 mg, are combined with post-flight Best Estimate Trajectory (BET) information and predicted, flight-substantiated Orbiter aerodynamics to provide determinations up to altitudes of 95 km. In some instances, alternate accelerometry data with micro-g resolution were utilized to extend the data base well into the thermosphere. Though somewhat limited, the ensemble of flights permit a reasonable sampling of monthly, seasonal, and latitudinal variations which can be utilized for atmospheric science investigations and model evaluations and upgrades as appropriate. More significantly, the unparallel vertical resolution in the Shuttle-derived results indicate density shears normally associated with internal gravity waves or local atmospheric instabilities. Consequently, these atmospheres can also be used as stress-atmospheres for Guidance, Navigation and Control (GN and C) system development and analysis as part of any advanced space vehicle design activities

STS-40 descent BET products: Development and results

Descent Best Estimate Trajectory (BET) Data were generated for the final Orbiter Experiments Flight, STS-40. This report discusses the actual development of these post-flight products: the inertial BET, the Extended BET, and the Aerodynamic BET. Summary results are also included. The inertial BET was determined based on processing Tracking and Data Relay Satellite (TDRSS) coherent Doppler data in conjunction with observations from eleven C-band stations, to include data from the Kwajalein Atoll and the usual California coastal radars, as well as data from five cinetheodolite cameras in the vicinity of the runways at EAFB. The anchor epoch utilized for the trajectory reconstruction was 53,904 Greenwich Mean Time (GMT) seconds which corresponds to an altitude at epoch of approximately 708 kft. Atmospheric data to enable development of an Extended BET for this mission were upsurped from the JSC operational post-flight BET. These data were evaluated based on Space Shuttle-derived considerations as well as model comparisons. The Aerodynamic BET includes configuration information, final mass properties, and both flight-determined and predicted aerodynamic performance estimates. The predicted data were based on the final pre-operational databook, updated to include flight determined incrementals based on an earlier ensemble of flights. Aerodynamic performance comparisons are presented and correlated versus statistical results based on twenty-two previous missions

OEXP Analysis Tools Workshop

This publication summarizes the software needs and available analysis tools presented at the OEXP Analysis Tools Workshop held at the NASA Langley Research Center, Hampton, Virginia on June 21 to 22, 1988. The objective of the workshop was to identify available spacecraft system (and subsystem) analysis and engineering design tools, and mission planning and analysis software that could be used for various NASA Office of Exploration (code Z) studies, specifically lunar and Mars missions

Final STS-35 Columbia descent BET products and results for LaRC OEX investigations

Final STS-35 'Columbia' descent Best Estimate Trajectory (BET) products have been developed for Langley Research Center (LaRC) Orbiter Experiments (OEX) investigations. Included are the reconstructed inertial trajectory profile; the Extended BET, which combines the inertial data and, in this instance, the National Weather Service atmospheric information obtained via Johnson Space Center; and the Aerodynamic BET. The inertial BET utilized Inertial Measurement Unit 1 (IMU1) dynamic measurements for deterministic propagation during the ENTREE estimation process. The final estimate was based on the considerable ground based C-band tracking coverage available as well as Tracking Data and Relay Satellite System (TDRSS) Doppler data, a unique use of the latter for endo-atmospheric flight determinations. The actual estimate required simultaneous solutions for the spacecraft position and velocity, spacecraft attitude, and six IMU parameters - three gyro biases and three accelerometer scale factor correction terms. The anchor epoch for this analysis was 19,200 Greenwich Mean Time (GMT) seconds which corresponds to an initial Shuttle altitude of approximately 513 kft. The atmospheric data incorporated were evaluated based on Shuttle derived considerations as well as comparisons with other models. The AEROBET was developed based on the Extended BET, the measured spacecraft configuration information, final mass properties, and the final Orbiter preoperation databook. The latter was updated based on aerodynamic consensus incrementals derived by the latest published FAD. The rectified predictions were compared versus the flight computed values and the resultant differences were correlated versus ensemble results for twenty-two previous STS entry flights

Solids maldistribution in parallel cyclones

The amount of solids maldistribution in parallel cyclones was investigated to determine what parameters affected the maldistribution. In many fluidized bed processes with parallel cyclones (as many as 20 in parallel in some cases), it has been noted that unequal erosion (wear) can occur in the cyclones. This results in very short run lengths in order to repair the cyclones with the most wear. This unequal wear has been attributed to unequal solids distribution to the cyclones. In addition to the increased wear, cyclone efficiencies are affected as well. In the specific concern that generated this study, it was found that parallel cyclones in fluidized-bed cokers at Syncrude Canada Ltd. (Syncrude) had unequal amounts of coke buildup on them. This coke buildup on the cyclones causes increased backpressure on the fluidized-bed coker, and after a certain pressure is reached, results in shutdown of the coker. Hot scouring coke, presented at the cyclone inlets, is used to combat the coke formation that is caused by condensation of heavy hydrocarbons. Understanding the scouring coke distribution into the parallel cyclones could lead to reduced deposit maldistribution and increased run length. The testing to determine what causes solids maldistribution in parallel cyclones was conducted using four, 30-cm diameter parallel cyclones that were located above a 0.9-m diameter fluidized bed. Solids flows into the freeboard above the fluidized bed were from the fluidized bed itself and from two pneumatic conveying lines that simulated the lines entering the freeboard of the Syncrude Canada Ltd (Syncrude) fluidized bed coker. The testing was conducted at ambient temperature and pressure using a coke material with a median particle size of 156 microns. The results of the testing showed that although the pressure drop across the cyclones were essentially equal, the gas and solids flow rates through the cyclones could vary significantly. By closing a valve in the dipleg of each of the test cyclones and measuring the rate of buildup of solids in each dipleg, the solids flow rate through each cyclone could be determined. Tests were conducted to vary the gas flow rate through the bed, the amount of solids flow through each pneumatic conveying line and the amount of gas flowing through each cyclone. Depending on conditions, it was found that the ratio of the solids flow rate through the highest-loaded cyclone to the lowest-loaded cyclone could be as much as a factor of four. It was found that the solids distribution in the freeboard above the bed determined the solids flow distribution into each cyclone. Changing the gas flow rate through the cyclone did not affect the solids distribution through the cyclones. It appears that the solids distribute to the cyclones based on the solids distribution at the entrance to the parallel cyclones. The gas flow then distributes itself in order to equalize the pressure drop across the cyclones

Cost-effectiveness of donepezil and memantine in moderate to severe Alzheimer's disease (the DOMINO-AD trial).

OBJECTIVE: Most investigations of pharmacotherapy for treating Alzheimer's disease focus on patients with mild-to-moderate symptoms, with little evidence to guide clinical decisions when symptoms become severe. We examined whether continuing donepezil, or commencing memantine, is cost-effective for community-dwelling, moderate-to-severe Alzheimer's disease patients. METHODS: Cost-effectiveness analysis was based on a 52-week, multicentre, double-blind, placebo-controlled, factorial clinical trial. A total of 295 community-dwelling patients with moderate/severe Alzheimer's disease, already treated with donepezil, were randomised to: (i) continue donepezil; (ii) discontinue donepezil; (iii) discontinue donepezil and start memantine; or (iv) continue donepezil and start memantine. RESULTS: Continuing donepezil for 52 weeks was more cost-effective than discontinuation, considering cognition, activities of daily living and health-related quality of life. Starting memantine was more cost-effective than donepezil discontinuation. Donepezil-memantine combined is not more cost-effective than donepezil alone. CONCLUSIONS: Robust evidence is now available to inform clinical decisions and commissioning strategies so as to improve patients' lives whilst making efficient use of available resources. Clinical guidelines for treating moderate/severe Alzheimer's disease, such as those issued by NICE in England and Wales, should be revisited. © 2016 The Authors. International Journal of Geriatric Psychiatry published by John Wiley & Sons Ltd

An evaluation of POSSUM and P-POSSUM scoring in predicting post-operative mortality in a level 1 critical care setting

Background POSSUM and P-POSSUM are used in the assessment of outcomes in surgical patients. Neither scoring systems’ accuracy has been established where a level 1 critical care facility (level 1 care ward) is available for perioperative care. We compared POSSUM and P-POSSUM predicted with observed mortality on a level 1 care ward. Methods A prospective, observational study was performed between May 2000 and June 2008. POSSUM and P-POSSUM scores were calculated for all postoperative patients who were admitted to the level 1 care ward. Data for post-operative mortality were obtained from hospital records for 2552 episodes of patient care. Observed vs expected mortality was compared using receiver operating characteristic (ROC) curves and the goodness of fit assessed using the Hosmer-Lemeshow equation. Results ROC curves show good discriminative ability between survivors and non-survivors for POSSUM and P-POSSUM. Physiological score had far higher discrimination than operative score. Both models showed poor calibration and poor goodness of fit (Hosmer-Lemeshow). Observed to expected (O:E) mortality ratio for POSSUM and P-POSSUM indicated significantly fewer than expected deaths in all deciles of risk. Conclusions Our data suggest a 30-60% reduction in O:E mortality. We suggest that the use of POSSUM models to predict mortality in patients admitted to level 1 care ward is inappropriate or that a recalibration of POSSUM is required to make it useful in a level 1 care ward setting

Elevated plasma levels of cardiac troponin-I predict left ventricular systolic dysfunction in patients with myotonic dystrophy type 1:A multicentre cohort follow-up study

Objective: High sensitivity plasma cardiac troponin-I (cTnI) is emerging as a strong predictor of cardiac events in a variety of settings. We have explored its utility in patients with myotonic dystrophy type 1 (DM1). Methods: 117 patients with DM1 were recruited from routine outpatient clinics across three health boards. A single measurement of cTnI was made using the ARCHITECT STAT Troponin I assay. Demographic, ECG, echocardiographic and other clinical data were obtained from electronic medical records. Follow up was for a mean of 23 months. Results: Fifty five females and 62 males (mean age 47.7 years) were included. Complete data were available for ECG in 107, echocardiography in 53. Muscle Impairment Rating Scale score was recorded for all patients. A highly significant excess (p = 0.0007) of DM1 patients presented with cTnI levels greater than the 99th centile of the range usually observed in the general population (9 patients; 7.6%). Three patients with elevated troponin were found to have left ventricular systolic dysfunction (LVSD), compared with four of those with normal range cTnI (33.3% versus 3.7%; p = 0.001). Sixty two patients had a cTnI level < 5ng/L, of whom only one had documented evidence of LVSD. Elevated cTnI was not predictive of severe conduction abnormalities on ECG, or presence of a cardiac device, nor did cTnI level correlate with muscle strength expressed by Muscle Impairment Rating Scale score. Conclusions: Plasma cTnI is highly elevated in some ambulatory patients with DM1 and shows promise as a tool to aid cardiac risk stratification, possibly by detecting myocardial involvement. Further studies with larger patient numbers are warranted to assess its utility in this setting

Does oculomotor inhibition of return influence fixation probability during scene search?

Oculomotor inhibition of return (IOR) is believed to facilitate scene scanning by decreasing the probability that gaze will return to a previously fixated location. This “foraging” hypothesis was tested during scene search and in response to sudden-onset probes at the immediately previous (one-back) fixation location. The latencies of saccades landing within 1º of the previous fixation location were elevated, consistent with oculomotor IOR. However, there was no decrease in the likelihood that the previous location would be fixated relative to distance-matched controls or an a priori baseline. Saccades exhibit an overall forward bias, but this is due to a general bias to move in the same direction and for the same distance as the last saccade (saccadic momentum) rather than to a spatially specific tendency to avoid previously fixated locations. We find no evidence that oculomotor IOR has a significant impact on return probability during scene search